Pendulum put the 'pro' in probiotics
Doctor-formulated
Founded by PhD doctors and scientists from Johns Hopkins, Harvard, Berkeley, and Stanford
Proprietary strains
Featuring strains you can't get anywhere else, including live Akkermansia, a keystone strain that's been in 3,000+ scientific
publications
Revolutionary manufacturing
Next-generation anaerobic strains are manufactured in our own strict, oxygen-free facility in the U.S.
Clinical efficacy
Created Glucose Control, the only medical probiotic on the market clinically shown to improve A1C in type 2 diabetes
Cutting-edge research
We continue to drive microbiome research forward through our own rigorous research and partnerships in clinical trials
Our first investor and continuing research partner. We are the first consumer microbiome company to co-develop a registry with the Mayo Clinic.
Our team has served as board members for ADA chapters and the ADA Research Foundation. Pendulum was profiled at the annual Scientific Sessions.
Akkermansia
Replenish your gut barrier with liveAkkermansia, a probiotic strain essential for gut health.
A healthy gut requires a strong, healthy gut barrier. Foundational strain, Akkermansia muciniphila plays a critical role in reversing the negative impact that factors like diet, lifestyle, and stress can have on your gut lining. We pioneered its use in probiotic supplements, and a single dose of our Akkermansia formula contains 100 million AFU of this potent live strain.
- Fortifies the gut lining*
- Reduces gut permeability*
- Supports overall gut health
*Based on preclinical studies.
Your best line of defense
Stress, repeated antibiotic use, and other external factors can degrade the integrity of your gut lining. When this happens, the toxins in your gut can more easily infiltrate your body. Another adverse effect is a reduction in the amount ofAkkermansia muciniphila, a naturally occurring bacterial strain essential for maintaining the integrity of your gut barrier and thus your overall gut health.
Akkermansia is a foundational strain that fortifies your gut lining, reduces gut permeability, and supports metabolic function.
Improve gut health and digestion
Pendulum Akkermansia reinforces the mucin layer of the gut lining*, reducing permeability* and supporting overall digestive comfort.
*Based on preclinical studies
**Based on a consumer survey of 172 people over 3 months
Reduce food cravings
Pendulum Akkermansia supports your gut lining and may influence the gut-brain axis—the communication pathway that helps regulate hunger signals. A stronger gut lining can help rebalance the signals that affect cravings and appetite.
*Based on a consumer survey of 80 people over 3 months
How Akkermansia fortifies your gut
1- RESET
The Akkermansia bacteria feeds on mucin, the thin protective layer that keeps your gut lining strong and less permeable.
2 - REPLENISH
As the Akkermansia consumes mucin, it stimulates your gut to produce new mucin.
3 - REINFORCE
Freshly produced mucin fortifies your gut barrier and keeps toxins from traveling to the rest of your body.
Recommended by more than 29,000 medical professionals.
Metabolic Daily
4-IN-1 DAILY PROBIOTIC: This 5-strain probiotic improves gut health, metabolism, mood and energy.
The connection between gut health and overall metabolic health is clearer today than ever before. We developed Metabolic Daily specifically to strengthen your gut in the service of key metabolic issues like poor utilization of nutrients and flagging energy levels.
- Supports a healthy gut for digestive health
- Helps metabolize sugars and carbs*
- Supports a healthy immune system
*Based on preclinical studies
Why Metabolic Daily
The goal of achieving peak metabolic health is only possible with a healthy, balanced gut microbiome. Decreased levels of keystone bacteria strains and a weakened gut barrier are two of the factors that can prevent you from utilizing nutrients effectively and lead to a drop in your energy level as the day wears on. Simply changing your diet and exercising may not be enough to fully balance your microbiome.
How it Works
1- CONVERTING FIBER INTO FUEL
Bacteria strains in Metabolic Daily convert fiber in your gut into butyrate, a short-chain fatty acid.
2 - IMPROVING GLP-1 PRODUCTION
Butyrate stimulates your gut cells to produce GLP-1*, a key hormone for metabolism.
3 - SUSTAINED ENERGY
With an optimized metabolism, you can more easily maintain your energy level throughout the day.
*This product is not intended for weight loss.
The right strains for metabolic health
Metabolic Daily is formulated with the most beneficial bacterial strains
Akkermansia muciniphila
An essential bacteria strain that strengthensthe all-important gut barrier and producespostbiotics for digestive and metabolichealth.
Clostridium butpricum
A prominent butyrate-producing strain that enhances metabolism, promotes digestive health, and supports immune health.
Anaerobutpricum
hallii
A butyrate-producing strain that plays anessential role in metabolic and digestivehealth.
Clostridium beijerinckii
A novel butyrate-producing strain that
promotes a healthy and balanced gut
microbiome.
Bifidobacter iuminjantis
A beneficial strain that primarily digests complex carbohydrates, thereby helping other bacteria produce short-chain fatty acids like butyrate. lts presence enhances digestion and supports healthy immune
function and microbiome balance.
DOCTOR FORMULATED
NON-GMO
3RD-PARTY TESTED
CLINICALLY STUDIED STRAINS
Our inspiration is our family. And yours.
We're a team of scientists, doctors, and innovators.But we're also a family, both at home and at work inour San Francisco-based headquarters. And like anytight-knit family, we're inspired by keeping each otherhealthy, happy, and well.
At Pendulum, we're passionate about findingrevolutionary, safe, and effective solutions to theailments that can be tied to our gut health. And givenour backgrounds in biostatistics, microbiologybiotechnology, and medical research, we recognizethat the key to discovering these solutions lies withinthe emerging field of microbiome science.
Our mission is to bridge nature and medicine
We understand that whole-body health and wellness is tied to the complex ecosystem of microorganisms that is the microbiome, and that addressing imbalances in the microbiome transform people’s lives from the inside.
Our mission is simple: to improve the lives of millions through microbiome products. To that end, we are creating products that have the power and efficacy of a pharmaceutical with the safety and accessibility of a probiotic.
More than a microbiome scientist, our pioneering CEO is a mom.
Colleen Cutcliffe has an impressive background leading and managing biology teams. She’s a scientist with a Ph.D. in Biochemistry and Microbiology from Johns Hopkins University and has held senior positions at bioscience and pharmaceutical firms. She’s also a mom, not to mention our CEO.
Colleen and her two co-founders, John and Jim, saw an opportunity to apply next-generation DNA sequencing technologies and microbiological assays to the emerging microbiome science space. Using these data, they could create metabolic maps of the microbiome and use systems biology to make novel insights into the microbiome. This scientific trio was uniquely positioned to bring new products to the world.
It was her role as a mom, however, that inspired her to team up with her two former colleagues and create Pendulum. Colleen’s first daughter was born eight weeks prematurely. That meant instead of heading home that day with mom and dad, she was whisked away to the NICU for four weeks, receiving multiple doses of antibiotics as a precautionary measure due to her fragile state.
Multiple publications have shown the longer term chronic risks associated with early antibiotics. This led Colleen, John and Jim on their journey to find a safe solution for those who struggle with chronic issues that are the result of a disrupted microbiome. And, this set the stage for the vision of the company to create a new generation of natural products that have proven efficacy.
After nearly a decade of research, Pendulum Glucose Control was born and remains a central part of Colleen and her daughter's wellness.
Colleen Cutcliffe
CEO AND CO-FOUNDER
Colleen Cutcliffe is the Chief Executive Officer and co-founder of Pendulum. She has more than 15 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. Prior to starting Pendulum, Colleen was the senior manager of biology at Pacific Biosciences and a scientist at Elan Pharmaceuticals. Colleen completed her postdoctoral studies at Northwestern’s Children’s Memorial Hospital. Colleen received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and her B.A. in Biochemistry from Wellesley College.
“I am excited to be at Pendulum working towards unlocking the promise of the microbiome and building products to improve the health and lives of millions of people. Leading a team of world-class experts in medicine, lab science, manufacturing, finance and commercialization who work together fantastically makes my job easy.”
Jim Bullard
CO-FOUNDER
Prior to co-founding Pendulum, Jim served as a senior staff scientist at Pacific Biosciences. He completed his Ph.D. in Biostatistics at the University of California, Berkeley and his B.A. in Computing & Information Systems at Northwestern University. He has a passion for experimental design, programming languages, and taking long walks with his dog.
“I feel fortunate to have worked with smart, motivated people on interesting problems. Building products that help people is incredibly motivating.”
John Eid
CSO AND CO-FOUNDER
John Eid is the Chief Science Officer and co-founder of Pendulum. John has led technology development teams for nearly two decades in diverse areas that include advanced microscopy, single molecular detection and analyses, automated data acquisition systems, biophysical systems modeling, and genome sequencing applications. Prior to co-founding Pendulum, John was a principal scientist at Pacific Biosciences. John completed his postdoctoral research at the Rowland Institute at Harvard University, received his Ph.D. in Biophysics and Computational Biology at the University of Illinois, Urbana Champaign and his B.S. in Applied and Engineering Physics from Cornell University.
“It is exciting to have a front row seat on the evolution of the microbiome field from a purely academic endeavor into a field that is actually helping people in the here and now.”
Adam Perlman
CHIEF MEDICAL OFFICER
Dr. Perlman is board-certified in Internal Medicine and specializes in both integrative and functional medicine. With more than 25 years of clinical, entrepreneurial, and leadership experience, he most recently served as the Director of Integrative Health and Wellbeing at the Mayo Clinic. Prior to that, he served as the Associate Vice President for Health and Wellness for the Duke University Health System. Dr. Perlman received his BA from Tufts University, his MD from the Boston University School of Medicine, and his MPH from the Boston University School of Public Health.
"It is critical to educate people on how a targeted approach to a healthy gut microbiome can positively affect overall health and wellbeing to help them improve vitality and live their best lives."
