Replenish your gut barrier with live Akkermansia, a probiotic strain essential for gut health.
A healthy gut requires a strong, healthy gut barrier. Foundational strain, Akkermansia muciniphila plays a critical role in reversing the negative impact that factors like diet, lifestyle, and stress can have on your gut lining. We pioneered its use in probiotic supplements, and a single dose of our Akkermansia formula contains 100 million AFU of this potent live strain.
*Based on preclinical studies.
Adults take one capsule daily with food. Store at room temperature.
Week 1 - 3 Initiation
You may experience mild digestive changes. This is usually temporary and indicates that the strains are simply settling into their new environment — your gut.
Month 1 - 2 Initial changes
It usually takes around 90 days to see changes in the microbiome. However, results vary based on your gut, and you may begin to feel some benefits.
Month 3+ Full benefits
Good things take time. By now, your gut microbiome is reset and your digestive function is supported. Your gut feels good and so do you. Reminder: health depends on habit formation and benefits are optimized with daily use.
Your best line of defense
Stress, repeated antibiotic use, and other external factors can degrade the integrity of your gut lining. When this happens, the toxins in your gut can more easily infiltrate your body. Another adverse effect is a reduction in the amount ofAkkermansia muciniphila, a naturally occurring bacterial strain essential for maintaining the integrity of your gut barrier and thus your overall gut health.
Pendulum Akkermansia reinforces the mucin layer of the gut lining*, reducing permeability* and supporting overall digestive comfort.
*Based on preclinical studies
**Based on a consumer survey of 172 people over 3 months
Pendulum Akkermansia supports your gut lining and may influence the gut-brain axis—the communication pathway that helps regulate hunger signals. A stronger gut lining can help rebalance the signals that affect cravings and appetite.
*Based on a consumer survey of 80 people over 3 months
Recommended by more than 29,000 medical professionals.
How Akkermansia fortifies your gut
1- RESET
The Akkermansia bacteria feeds on mucin, the thin protective layer that keeps your gut lining strong and less permeable.
2 - REPLENISH
As the Akkermansia consumes mucin, it stimulates your gut to produce new mucin.
3 - REINFORCE
Freshly produced mucin fortifies your gut barrier and keeps toxins from traveling to the rest of your body.
DOCTOR FORMULATED
NON-GMO
3RD-PARTY TESTED
CLINICALLY STUDIED STRAINS
Crucial for my recovery
"When l was trying to recover from the greatest health crisis of my life.Akkermansia muciniphila played apivotal role. lt's crucial for optimizing gut barrier function and immune response."
Dr. Mark Hyman, MD
Family Physician, Functional Medicine
About Akkermansia
Longterm impact for patients
"Having the ability to replace Akkermansia and combining it with the right dietary factors has made an incredible difference in both my patients' metabolic and gut health."
Jana Davis, MS, RDN,CDCES
Functional Registered Dietitian Nutritionist
About Akkermansia
Benefits beyond digestion
"So many of my clients have low levels of Akkermansia identified on their gut microbiome tests. Being able to provide the microbiome with what it specifically needs, coupled with lifestyle interventions, helps me optimize not only my client's gut but overall health and wellbeing."
Anne Easthope
Nurse Practioner, Functiona Medicine
About Akkermansia
Our inspiration is our family. And yours.
We're a team of scientists, doctors, and innovators.But we're also a family, both at home and at work inour San Francisco-based headquarters. And like anytight-knit family, we're inspired by keeping each otherhealthy, happy, and well.
At Pendulum, we're passionate about findingrevolutionary, safe, and effective solutions to theailments that can be tied to our gut health. And givenour backgrounds in biostatistics, microbiologybiotechnology, and medical research, we recognizethat the key to discovering these solutions lies withinthe emerging field of microbiome science.
We understand that whole-body health and wellness is tied to the complex ecosystem of microorganisms that is the microbiome, and that addressing imbalances in the microbiome transform people’s lives from the inside.
Our mission is simple: to improve the lives of millions through microbiome products. To that end, we are creating products that have the power and efficacy of a pharmaceutical with the safety and accessibility of a probiotic.
Colleen Cutcliffe has an impressive background leading and managing biology teams. She’s a scientist with a Ph.D. in Biochemistry and Microbiology from Johns Hopkins University and has held senior positions at bioscience and pharmaceutical firms. She’s also a mom, not to mention our CEO.
Colleen and her two co-founders, John and Jim, saw an opportunity to apply next-generation DNA sequencing technologies and microbiological assays to the emerging microbiome science space. Using these data, they could create metabolic maps of the microbiome and use systems biology to make novel insights into the microbiome. This scientific trio was uniquely positioned to bring new products to the world.
It was her role as a mom, however, that inspired her to team up with her two former colleagues and create Pendulum. Colleen’s first daughter was born eight weeks prematurely. That meant instead of heading home that day with mom and dad, she was whisked away to the NICU for four weeks, receiving multiple doses of antibiotics as a precautionary measure due to her fragile state.
Multiple publications have shown the longer term chronic risks associated with early antibiotics. This led Colleen, John and Jim on their journey to find a safe solution for those who struggle with chronic issues that are the result of a disrupted microbiome. And, this set the stage for the vision of the company to create a new generation of natural products that have proven efficacy.
After nearly a decade of research, Pendulum Glucose Control was born and remains a central part of Colleen and her daughter's wellness.
Colleen Cutcliffe
CEO AND CO-FOUNDER
Colleen Cutcliffe is the Chief Executive Officer and co-founder of Pendulum. She has more than 15 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. Prior to starting Pendulum, Colleen was the senior manager of biology at Pacific Biosciences and a scientist at Elan Pharmaceuticals. Colleen completed her postdoctoral studies at Northwestern’s Children’s Memorial Hospital. Colleen received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and her B.A. in Biochemistry from Wellesley College.
“I am excited to be at Pendulum working towards unlocking the promise of the microbiome and building products to improve the health and lives of millions of people. Leading a team of world-class experts in medicine, lab science, manufacturing, finance and commercialization who work together fantastically makes my job easy.”
Jim Bullard
CO-FOUNDER
Prior to co-founding Pendulum, Jim served as a senior staff scientist at Pacific Biosciences. He completed his Ph.D. in Biostatistics at the University of California, Berkeley and his B.A. in Computing & Information Systems at Northwestern University. He has a passion for experimental design, programming languages, and taking long walks with his dog.
“I feel fortunate to have worked with smart, motivated people on interesting problems. Building products that help people is incredibly motivating.”
John Eid
CSO AND CO-FOUNDER
John Eid is the Chief Science Officer and co-founder of Pendulum. John has led technology development teams for nearly two decades in diverse areas that include advanced microscopy, single molecular detection and analyses, automated data acquisition systems, biophysical systems modeling, and genome sequencing applications. Prior to co-founding Pendulum, John was a principal scientist at Pacific Biosciences. John completed his postdoctoral research at the Rowland Institute at Harvard University, received his Ph.D. in Biophysics and Computational Biology at the University of Illinois, Urbana Champaign and his B.S. in Applied and Engineering Physics from Cornell University.
“It is exciting to have a front row seat on the evolution of the microbiome field from a purely academic endeavor into a field that is actually helping people in the here and now.”
Adam Perlman
CHIEF MEDICAL OFFICER
Dr. Perlman is board-certified in Internal Medicine and specializes in both integrative and functional medicine. With more than 25 years of clinical, entrepreneurial, and leadership experience, he most recently served as the Director of Integrative Health and Wellbeing at the Mayo Clinic. Prior to that, he served as the Associate Vice President for Health and Wellness for the Duke University Health System. Dr. Perlman received his BA from Tufts University, his MD from the Boston University School of Medicine, and his MPH from the Boston University School of Public Health.
"It is critical to educate people on how a targeted approach to a healthy gut microbiome can positively affect overall health and wellbeing to help them improve vitality and live their best lives."
Are there studies that show that Akkermansia improves gut health?
Yes, there are studies suggesting thatAkkermansia muciniphila, a species of bacteria found in the gut, improves gut health.
What consumer surveys have been done on Akkermansia?
In a consumer study of 172 people taking Akkermansia over 12 weeks of product use, 82% reported improved bowel movements, 77% reported improved GI/gut health, 71% reported reduced occasional gas & bloating, and 67% reported reduced diarrhea. In a separate consumer study of 86 people taking Akkermansia for 3 months, 91% reported reduced overall food cravings and 86% reported reduced sugar cravings.
How does Akkermansia compare to other Pendulum products, and which one is right for me?
Akkermansia is a single-strain probiotic, meaning it only contains the live Akkermansia muciniphila strain.
You might notice that our multi-strain probiotics also contain Akkermansia. That’s because we so deeply believe in the power and efficacy of this keystone strain for gut health that we use it in all of our formulations.
Is Akkermansia safe?
Akkermansia contains Akkermansia muciniphila, a beneficial bacterial strain naturally found in the human gut of people with healthy microbiomes. Akkermansia muciniphila has undergone extensive safety studies and found to be safe.
Can or should I take Akkermansia if I’m pregnant?
Akkermansia contains a beneficial bacterial strain that exists within the gut microbiome of healthy people, including during pregnancy. To date, Akkermansia has not been studied in women who are either pregnant, planning to become pregnant, or breastfeeding. Please consult with your healthcare provider to see if this product may be a good fit for you.
Are there any side effects of taking Akkermansia?
When starting any new probiotic such as Akkermansia, there can be an adjustment period. You may experience some gastrointestinal symptoms (increased gas, bloating, nausea, or loose stools) that usually resolve over the initial 14 days or with discontinuation of the product. If you experience symptoms that are severe or do not resolve, please consult your healthcare provider.
How long should Akkermansia be taken?
Akkermansia is a daily supplement and can be taken for as long as you experience benefits.
Should someone lower their dose after taking for 60, 90, 180 days?
To maintain the benefits of Akkermansia, we do not recommend lowering the dose.
Can I travel with Akkermansia?
You can travel with Akkermansia. Just toss your bottle in your bag and once you reach your destination, put it in the fridge if possible. Refrigeration is best though not required.
What lifestyle habits should someone adjust to maximize the benefits of Akkermansia?
A diet filled with colorful fruits, vegetables, polyphenols, and a wide range of dietary fibers supports a healthy gut microbiome and will maximize the benefits of Akkermansia. It’s also important to maintain healthy stress levels and remain physically active.
Will the effects plateau after a certain amount of time?
Akkermansia is designed to improve your gut health and should continue supporting your gut microbiome for as long as you take the product.
